993 research outputs found
Short-term fate of phytodetritus in sediments across the arabian sea oxygen minimum zone
The short-term fate of phytodetritus was investigated across the Pakistan margin of the Arabian Sea at water depths ranging from 140 to 1850 m, encompassing the oxygen minimum zone (~100–1100 m). Phytodetritus sedimentation events were simulated by adding ~44 mmol 13C-labelled algal material per m2 to surface sediments in retrieved cores. Cores were incubated in the dark, at in situ temperature and oxygen concentrations. Overlying waters were sampled periodically, and cores were recovered and sampled (for organisms and sediments) after durations of two and five days. The labelled carbon was subsequently traced into bacterial lipids, foraminiferan and macrofaunal biomass, and dissolved organic and inorganic pools. The majority of the label (20 to 100%) was in most cases left unprocessed in the sediment at the surface. The largest pool of processed carbon was found to be respiration (0 to 25% of added carbon), recovered as dissolved inorganic carbon. Both temperature and oxygen were found to influence the rate of respiration. Macrofaunal influence was most pronounced at the lower part of the oxygen minimum zone where it contributed 11% to the processing of phytodetritus
Bubbles from Nothing
Within the framework of flux compactifications, we construct an instanton
describing the quantum creation of an open universe from nothing. The solution
has many features in common with the smooth 6d bubble of nothing solutions
discussed recently, where the spacetime is described by a 4d compactification
of a 6d Einstein-Maxwell theory on S^2 stabilized by flux. The four-dimensional
description of this instanton reduces to that of Hawking and Turok. The choice
of parameters uniquely determines all future evolution, which we additionally
find to be stable against bubble of nothing instabilities.Comment: 19 pages, 6 figure
Truncated glucagon-like peptide I, an insulin-releasing hormone from the distal gut
AbstractBy hydrophobic gel permeation and high pressure liquid chromatography we isolated from pig intestinal mucosa a peptide which corresponds to proglucagon 78–107 as suggested by chromatography and determination of its N-terminal sequence. Natural and synthetic proglucagon 78–107 dose dependently and potently increased insulin secretion from the isolated perfused pig pancreas. Proglucagon 78–107 also secreted by the small intestine may participate in the hormonal control of insulin secretion
Decay of flux vacua to nothing
We construct instanton solutions describing the decay of flux
compactifications of a gauge theory by generalizing the Kaluza-Klein
bubble of nothing. The surface of the bubble is described by a smooth
magnetically charged solitonic brane whose asymptotic flux is precisely that
responsible for stabilizing the 4d compactification. We describe several
instances of bubble geometries for the various vacua occurring in a
Einstein-Maxwell theory namely, AdS_4 x S^2, R^{1,3} x S^2, and dS_4 x S^2.
Unlike conventional solutions, the bubbles of nothing introduced here occur
where a {\em two}-sphere compactification manifold homogeneously degenerates.Comment: 31 pages, 15 figure
Measures for a Transdimensional Multiverse
The multiverse/landscape paradigm that has emerged from eternal inflation and
string theory, describes a large-scale multiverse populated by "pocket
universes" which come in a huge variety of different types, including different
dimensionalities. In order to make predictions in the multiverse, we need a
probability measure. In landscapes, the scale factor cutoff measure
has been previously shown to have a number of attractive properties. Here we
consider possible generalizations of this measure to a transdimensional
multiverse. We find that a straightforward extension of scale factor cutoff to
the transdimensional case gives a measure that strongly disfavors large amounts
of slow-roll inflation and predicts low values for the density parameter
, in conflict with observations. A suitable generalization, which
retains all the good properties of the original measure, is the "volume factor"
cutoff, which regularizes the infinite spacetime volume using cutoff surfaces
of constant volume expansion factor.Comment: 30 pages, 1 figure Minor revisions, reference adde
Mind, rationality, and cognition: an interdisciplinary debate
This article features an interdisciplinary debate and dialogue about the nature of mind, perception, and rationality. Scholars from a range of disciplines—cognitive science, applied and experimental psychology, behavioral economics, and biology—offer critiques and commentaries of a target article by Felin, Koenderink, and Krueger (2017): “Rationality, Perception, and the All-Seeing Eye,” Psychonomic Bulletin & Review. The commentaries raise a number of criticisms and issues concerning rationality and the all-seeing-eye argument, including the nature of judgment and reasoning, biases versus heuristics, organism–environment relations, perception and situational construal, equilibrium analysis in economics, efficient markets, and the nature of empirical observation and the scientific method. The debated topics have far-reaching consequences for the rationality literature specifically, as well as for the cognitive, psychological, and economic sciences more broadly. The commentaries are followed by a response from the authors of the target article. Their response is organized around three central issues: (1) the problem of cues; (2) what is the question?; and (3) equilibria, $500 bills, and the axioms of rationality
Clinical activity of ipilimumab for metastatic uveal melanoma: a retrospective review of the Dana-Farber Cancer Institute, Massachusetts General Hospital, Memorial Sloan-Kettering Cancer Center, and University Hospital of Lausanne experience.
BACKGROUND: Uveal melanoma exhibits a high incidence of metastases; and, to date, there is no systemic therapy that clearly improves outcomes. The anticytotoxic T-lymphocyte-associated protein 4 (anti-CTLA-4) antibody ipilimumab is a standard of care for metastatic melanoma; however, the clinical activity of CTLA-4 inhibition in patients with metastatic uveal melanoma is poorly defined.
METHODS: To assess ipilimumab in this setting, the authors performed a multicenter, retrospective analysis of 4 hospitals in the United States and Europe. Clinical characteristics, toxicities, and radiographic disease burden, as determined by central, blinded radiology review, were evaluated.
RESULTS: Thirty-nine patients with uveal melanoma were identified, including 34 patients who received 3 mg/kg ipilimumab and 5 who received 10 mg/kg ipilimumab. Immune-related response criteria and modified World Health Organization criteria were used to assess the response rate (RR) and the combined response plus stable disease (SD) rate after 12 weeks, after 23 weeks, and overall (median follow-up, 50.4 weeks [12.6 months]). At week 12, the RR was 2.6%, and the response plus SD rate was 46.%; at week 23, the RR was 2.6%, and the response plus SD rate was 28.2%. There was 1 complete response and 1 late partial response (at 100 weeks after initial SD) for an immune-related RR of 5.1%. Immune-related adverse events were observed in 28 patients (71.8%) and included 7 (17.9%) grade 3 and 4 events. Immune-related adverse events were more frequent in patients who received 10 mg/kg ipilimumab than in those who received 3 mg/kg ipilimumab. The median overall survival from the first dose of ipilimumab was 9.6 months (95% confidence interval, 6.3-13.4 months; range, 1.6-41.6 months). Performance status, lactate dehydrogenase level, and an absolute lymphocyte count ≥ 1000 cells/μL at week 7 were associated significantly with survival.
CONCLUSIONS: In this multicenter, retrospective analysis of 4 hospitals in the United States and Europe of patients with uveal melanoma, durable responses to ipilimumab and manageable toxicity were observed
Salinity tolerance of diapausing eggs of freshwater zooplankton
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/73091/1/j.1365-2427.2004.01185.x.pd
Branching Fractions for D0 -> K+K- and D0 -> pi+pi-, and a Search for CP Violation in D0 Decays
Using the large hadroproduced charm sample collected in experiment E791 at
Fermilab, we have measured ratios of branching fractions for the two-body
singly-Cabibbo-suppressed charged decays of the D0:
(D0 -> KK)/(D0 -> Kpi) = 0.109 +- 0.003 +- 0.003,
(D0 -> pipi)/(D0 -> Kpi) = 0.040 +- 0.002 +- 0.003, and
(D0 -> KK)/(D0 -> pipi) = 2.75 +- 0.15 +- 0.16. We have looked for
differences in the decay rates of D0 and D0bar to the CP eigenstates K+K- and
pi+pi-, and have measured the CP asymmetry parameters
A_CP(K+K-) = -0.010 +- 0.049 +- 0.012 and
A_CP(pi+pi-) = -0.049 +- 0.078 +- 0.030, both consistent with zero.Comment: 10 Postscript pages, including 2 figures. Submitted to Phys. Lett.
- …